Based on reports, Friends star Matthew Perry’s death has been concluded, and it’s accute effects of ketamine.

After 7 weeks from his death, the reports were released. Toxicology tests found a short-acting anaesthetic with hallucinogenic properties, in his body at high levels within the range typically associated with general anaesthesia used in surgical care.

"Matthew Perry's cause of death is determined to be from the acute effects of ketamine," the autopsy concluded.

Coronary artery disease, the effects of the opioid-addiction medicine buprenorphine, also detected in his system, and drowning were listed as contributing factors in his death, which was ruled an accident.

The concentrations of ketamine in Perry's body would have overstimulated his heart rate while depressing his breathing, likely leading him to lapse into unconsciousness before his face slipped below the water in the hot tub, the report said.

"The exact method of intake in Mr Perry's case is unknown," the report said, adding that trace amounts of the drug showed up in his stomach. No recent needle marks were found on his body.

The findings suggested that Matthew may have been self-medicating with ketamine between medically supervised treatments with the drug.

According to witnesses, Perry had been undergoing ketamine infusion therapy for depression and anxiety. But his last known treatment was a week and a half before his death, so the ketamine found in his system by medical examiners would have been introduced since that last infusion.

No alcohol, illicit drugs or drug paraphernalia was found at the scene of his death. Multiple nicotine vaping products and an inhaler were in hi living room. Injectables of the anti-diabetes medication tirzepatide and nicotine lollipops, in the refrigerator.

He had stopped smoking two weeks earlier, and been prescribed Tamoxifen a hormone regulator usually taken for breast cancer prevention for weight loss, was also receiving testosterone shots.

Non-toxic levels of some prescription medications were detected in his body, but there were no traces of alcohol, cocaine, heroin or other illegal narcotics.